Advice to an aging scientist.

نویسندگان

  • Daniel E L Promislow
  • Scott D Pletcher
چکیده

Fifty years ago, Peter Medawar and George Williams developed two now-classic theories for the evolution of senescence. In the past 20 years, evolutionary biologists studying aging have developed explicit mathematical models of these theories, used these models to derive explicit predictions, and tested these predictions using a variety of approaches. But, we argue here, our singular focus on these models may have hindered progress in evolutionary studies of aging. Research in this area has not kept pace with dramatic advances in evolutionary theory and molecular genetics. Progress in evolutionary studies of aging will depend on a bold, integrative approach, incorporating evolutionary and molecular advances from other fields, along with the powerful statistical and mathematical tools now available. We discuss several specific examples where we may gain new insight into the causes of aging by looking to other evolutionary phenomena, including sexual conflict and the evolution of social behavior. In addition, we present new results which suggest that the analysis of gene networks may lend particular insight into the genetic underpinnings of the aging process.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

فقط یک انسان خوب می تواند طبیبی خوب باشد

Imam Ali (peace be upon him) told that physicians must have pietism and don’t abstain from guidance, advice and diligence. Islam religion recognizes medicine as an allowable and necessary profession.  Prophet Mohammad (PBUH) and Imams (PBUH) tell that sage physician status in their science, art and tasks like jurisconsult scientist status. More than one thousand years ago, Abubakr Rabei Ebne Ah...

متن کامل

Sarcopenia: biomarkers and imaging (International Conference on Sarcopenia research).

1. Gerontopole Toulouse, Department of Geriatric Medicine, Toulouse University Hospital, Toulouse France, INSERM 1027; 2. Vice President, Clinical Research & Operations, Neuroscience & Neuromuscular Disorders, Cytokinetics, Inc. 280 East Grand Avenue, South San Francisco, CA 94080, USA; 3. Neurotune AG, Wagistr. 27A, 8952 Schlieren, Switzerland; 4. Senior Scientist and Director, Nutrition, Exer...

متن کامل

Web-site-based tailored advice to promote strength and balance training: an experimental evaluation.

This study evaluated a Web site providing tailored advice to encourage older people to undertake strength and balance training (SBT). Adults age 60-88 (N = 302) were randomized to read either generic advice or advice tailored to their self-perceived balance problems and activity preferences. Between-groups differences in attitudes toward SBT after reading the advice did not quite reach signific...

متن کامل

Discharge against Medical Advice: an Interventional Study

Background and Objectives: Discharge against medical advice (DAMA) is a significant healthcare problem posing negative impact on effectiveness of patient care and costs of the health system. In order to address this problem, first the potential influencing factor should be identifies. This study followed two major objectives: first, to evaluate the prevalence and potential causes of DAMA, and s...

متن کامل

Beneficial effects of medical advice provided to elderly persons under the anti-aging health check-up system at Tokai University Tokyo Hospital.

OBJECTIVE Tokai University Tokyo Hospital implemented its holistic anti-aging health check-up system in June 2006. This system is characterized by more than 70 check items and the provision of individual post-diagnostic advice of far greater detail than an ordinary health check-up. We analyzed aging-related changes in subjects who had completed their second check-up in order to determine the di...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:
  • Mechanisms of ageing and development

دوره 123 8  شماره 

صفحات  -

تاریخ انتشار 2002